Editorial The failing human heart *
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منابع مشابه
Activation of matrix metalloproteinases in the failing human heart: breaking the tie that binds.
The process of left ventricular (LV) remodeling has been shown to be an important predictor of morbidity and mortality in patients with heart failure. Therefore, identifying the cascade of molecular and cellular events that contribute to LV remodeling is likely to provide new and novel targets for preventing disease progression in heart failure. In this issue of Circulation, Li and colleagues r...
متن کاملRenin-angiotensin system in human failing hearts: message from nonmyocyte cells to myocytes.
The survival benefit conferred by angiotensinconverting enzyme (ACE) inhibitors in patients with heart failure has led to an intense interest in the mechanisms underlying the action of angiotensin II.1,2 However, ACE inhibition therapy does not completely block angiotensin II production, and in some patients angiotensin II remains elevated, in part because of the conversion of angiotensin I to ...
متن کاملThe effects of ginsenoside Rb1 on fatty acid β-oxidation, mediated by AMPK, in the failing heart
Objective(s): This study intended to investigate the effects of Ginsenoside-Rbl (Gs-Rbl) on fatty acid β-oxidation (FAO) in rat failing heart and to identify potential mechanisms of Gs-Rbl improving heart failure (HF) by FAO pathway dependent on AMP-activated protein kinase (AMPK). Materials and Methods: Rats with chronic HF, induced by adriamycin (Adr), were randomly grouped into 7 groups. Gs-...
متن کاملSomething old, something new: changing views on the cellular mechanisms of heart failure.
Despite improvements in therapy, mortality in heart failure (HF) remains high, and there is a need for alternative and additional approaches [1,2]. The possibility of replacement and/or supporting the failing heart with new cardiomyocytes from stem cells, implanted or recruited locally, is one of the exciting possibilities under investigation [3]. Other approaches aim at improving the function ...
متن کاملImmunolocalization of annexins IV, V and VI in the failing and non-failing human heart.
UNLABELLED The failing human heart is characterized by changes in the expression and function of proteins involved in intracellular Ca2+ cycling, resulting in altered Ca2+ transients and impaired contractile properties of cardiac muscle. The role of the cardiac annexins in this process remains unclear. Annexins may play a role in the regulation of Ca2+ pumps and exchangers on the sarcolemma, an...
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